Nghiên cứu bào chế vi cầu metformin hydroclorid giải phóng kéo dài bằng phương pháp bốc hơi dung môi từ nhũ tương

The aim of current study was to prepare ethyl cellulose-based microspheres containing metformin hydrochloride which release in an extended manner. The preparation was performed by solvent extraction evaporation method using solid-in-oil-in-water emulsification technique. The formulation and process factors (i.e. polymer type, solvent type, polymer concentration and emulsification speed) were tuned to achieve desired microsphere. As the results, the formulation employing ethyl cellulose 45 cps, ethyl acetate as solvent, polymer concentration at 100 mg/mL concomitantly with emulsification speed at 2000 rpm could be used to prepare microspheres having drug loading at 12.51% and the mean diameter of 266.0 ± 6.5 µm. The drug release from resultant microspheres was controlled with approximately 90% metformin hydrochloride released after 24 hours. The release kinetics complied with Korsmeyer-Peppas model. Therefore, the release mechanism was controlled by diffusion and polymer erosion simultaneously. The achieved microspheres could be used as component for sustained release dosage forms. 

Keywords: Polymeric microsphere, ethyl cellulose, metformin, extended release.